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Institution
Universitätsklinikum Erlangen AöR
Virologisches Institut - Klinische und Molekulare Virologie
Address
Schloßgarten 4
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Research Grants
Current projects
Assessing the functional relevance of the isomerase Pin1 for the modulation of herpesviral polymerase complexes
(Applicants
Marschall, Manfred
;
Sticht, Heinrich
)
Elucidating the virus-host interface to inhibit transmission of Human T-cell leukemia virus type 1 (HTLV-1)
(Applicant
Thoma-Kreß, Andrea Karin
)
Exploring the cytomegalovirus-specific nuclear egress complex as a central determinant of viral replication efficiency and host interaction
(Applicants
Eichler, Jutta
;
Marschall, Manfred
)
Completed projects
Adoptiver Transfer von Cytomegalovirus-spezifischen Gedächtnis B-Zellen: Immunologische Mechanismen der sekundären Antikörperantwort
(Applicant
Mach, Michael
)
Analysis of the TRIM5α-mediated restriction of retrotransposons
(Applicant
Gramberg, Thomas
)
Characterization of the SAMHD1-mediated restriction to lentiviral infection counteracted by Vpx and analyzing its role in innate immunity
(Applicant
Gramberg, Thomas
)
Charakterisierung eines neuen Adenovirus aus der Maus
(Applicants
Krüger, Detlev H.
;
Überla, Klaus
)
Das Rhadinovirale Onkoprotein Tip in der T-Zell-Transformation
(Applicant
Ensser, Armin
)
Die Bedeutung des viralen Glykoproteins gpUL132 des humanen Cytomegalovirus für Morphogenese und Virusreplikation
(Applicant
Mach, Michael
)
Die Immunantwort gegen die Glykoproteine B und H des humanen Cytomegalovirus. Molekulare Analyse und Beteiligung an der Induktion von Autoimmunprozessen
(Applicant
Mach, Michael
)
Einfluss lentiviraler Gene auf die Differenzierung und Funktion von Dendritischen Zellen
(Applicant
Überla, Klaus
)
Enhanced respiratory syncytial virus disease or protection from infection depends on the subtype used for adenoviral vector vaccination
(Applicant
Tenbusch, Matthias
)
Gammaherpesviral tegument proteins - crucial effectors of viral infection
(Applicant
Ensser, Armin
)
Genetic and functional basis of familial hemophagocytic lymphohistiocytosis
(Applicants
Ehl, Stephan
;
Hennies, Ph.D., Hans-Christian
)
Intrinsic immune sensing of retroviral infections in SAMHD1 knockout mice
(Applicant
Gramberg, Thomas
)
Mechanismen der Persistenz humaner Immundefizienz-Viren (HIV) in verschiedenen humanen Zellpopulationen peripherer mononukleärer Zellen
(Applicant
Metzner, Karin
)
Mechanism of enhancement of RNA packaging by Rev proteins of immunodeficiency viruses
(Applicant
Überla, Klaus
)
Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model
(Applicant
Überla, Klaus
)
Mechanistic investigation of the antiviral drug artesunate and its optimized synthetic derivatives
(Applicants
Marschall, Manfred
;
Tsogoeva, Svetlana
)
Modulation von Differenzierungs- und Überlebenssignalen von T-Lymphozyten bei der Transformation durch das menschliche T-Zell Leukämievirus (HTLV-1)
(Applicant
Fleckenstein, Bernhard
)
Molekulare Struktur des HIV-1 p6 Proteins und dessen Funktion in späten Prozessen der Virusreplikation
(Applicant
Schubert, Ulrich
)
Multifunctional calcium phosphate nanoparticles as novel HIV-1 vaccine platform
(Applicants
Epple, Matthias
;
Temchura, Vladimir
;
Überla, Klaus
)
Patterns of viral gene expression in Adenovirus type 12-infected and transformed cells and in Ad12-induced tumors.
(Applicant
Doerfler, Walter
)
Peptidyl-prolyl isomerase Pin1 as a multifunctional regulator of cytomegalovirus replication
(Applicant
Marschall, Manfred
)
Regulatory interaction between cellular cyclins and the cyclin-dependent protein kinase ortholog pUL97 of human cytomegalovirus
(Applicants
Marschall, Manfred
;
Sticht, Heinrich
)
Reinigung und Charakterisierung von Proteinen, die die Integration von Adenovirus Typ 12 DNA in das Hamsterzellgenom katalysieren
(Applicant
Doerfler, Walter
)
Relevance of Fc-effector functions for prevention of infection of the first cell in the HIV nonhuman primate model
(Applicants
Stahl-Hennig, Christiane
;
Überla, Klaus
)
Restrukturierung der nukleären Lamina durch herpesvirale Proteinkinasen: neue Zielmechanismen für die antivirale Therapie
(Applicant
Marschall, Manfred
)
Signal transducing complexes induced by the herpesvirus ateles oncoprotein Tio in human T cells
(Applicant
Biesinger-Zwosta, Brigitte
)
The gM/gN complex of human cytomegalovirus. Structural and immunological aspects
(Applicant
Mach, Michael
)
The humoral immune response to glycoprotein B of human cytomegalovirus
(Applicant
Mach, Michael
)
The regulatory role of cyclin-dependent protein kinases in human cytomegalovirus replication
(Applicant
Marschall, Manfred
)
The role of Ephrin-A2 receptor-tyrosinkinase in Kaposi sarcoma-associated herpesvirus infection
(Applicant
Neipel, Frank
)
The role of TRIM-family proteins and other host cell factors in the restriction of SARS-CoV-2
(Applicant
Ensser, Armin
)
Virale Determinanten der präferentiellen Integration lentiviraler Vektoren in transkriptionell-aktive Bereiche
(Applicant
Überla, Klaus
)
Zum epigenetischen Profil integrierter HIV-Genome bei HIV Infizierten: Korrelation mit dem Verlauf der Infektion
(Applicant
Doerfler, Walter
)
Heisenberg Fellowships
Completed projects
Experimentelle Virologie
(Applicant
Schubert, Ulrich
)
Research Fellowships
Completed projects
Funktionelle Charakterisierung der viralen FLICE-inhibierenden Proteine (vFLIP) MC159 und MC160 des Molluscum contagiosum Virus (MCV)
(Applicant
Thurau, Mathias
)
Physiological Role of APOBEC3
(Applicant
Gramberg, Thomas
)
Priority Programmes
Completed projects
Role of ubiquitin in retrovirus budding
(Applicant
Schubert, Ulrich
)
Collaborative Research Centres
Completed projects
Adoptiver Transfer von Cytomegalovirus-spezifischen Gedächtnis B-Zellen: Einfluss auf den Verlauf der Infektion und immunologische Mechanismen der sekundären Antikörperantwort
(Project Heads
Mach, Michael
;
Winkler, Thomas
)
Adoptive Transfer of cytomegalovirus-specific memory B-cells: Implementation of a Phase I/IIa clinical study
(Project Heads
Mach, Michael
;
Winkler, Thomas
;
Winkler, Julia
)
Adoptive transfer of Cytomegalovirus-specific memory B cells: Mechnisms of protection
(Project Heads
Mach, Michael
;
Winkler, Thomas
)
Charakterisierung von Pathogenese-relevanten Funktionen von SIV Nef
(Project Head
Lang, Sabine Martha
)
Das Humane Herpesvirus-8 - seine Beziehung zur Proliferation B-lymphoider Zellen in Lymphozyten
(Project Heads
Gramatzki, Martin
;
Neipel, Frank
)
Effects of Tax and p8 proteins on cell-to-cell transmission of Human T-cell lymphotropic virus type 1 (HTLV-1)
(Project Head
Thoma-Kreß, Andrea Karin
)
Funktionen des Ubiquitin-Proteasom-Systems (UPS) in späten Prozessen der Retrovirusreplikation
(Project Head
Schubert, Ulrich
)
Identification of viral and cellular degradation signals that regulate MHC-I antigen presentation
(Project Head
Schubert, Ulrich
)
Interaction of the HIV-1 regulatory virus protein R (Vpr) with host cell factors
(Project Head
Schubert, Ulrich
)
Interaktion von Rhadinovirus-Proteinen mit zellulären Signalketten
(Project Head
Biesinger-Zwosta, Brigitte
)
Mechanismen der Persistenz humaner Immundefizienz-Viren (HIV)
(Project Head
Metzner, Karin
)
Protektive Effektormechanismen nach Infektion mit attenuierten Affen-Immundefizienzviren
(Project Head
Überla, Klaus
)
Regulation of nuclear egress of human cytomegalovirus through a multifunctional viral-cellular protein complex
(Project Head
Marschall, Manfred
)
Rhadionvirales Ox-2 als Suppressor von Th1-Tyzokinwirkungen. Pathogenitische Bedeutung und Identifizierung therapeutischer Targets
(Project Head
Ensser, Armin
)
SFB 466: Lymphoproliferation and viral immunodeficiency
(Spokesperson
Fleckenstein, Bernhard
)
STAT-Activation in T-cell growth transformation
(Project Head
Ensser, Armin
)
Stimulation der G1-Phase im Zellzyklus durch menschliche T-Zell-Leukämieviren
(Project Head
Grassmann, Ralph
)
Transformierende und Transformations-assoziierte Gene von Rhadinoviren
(Project Heads
Ensser, Armin
;
Fleckenstein, Bernhard
)
Untersuchungen zur Gentherapie maligner Lymphome
(Project Head
Doerfler, Walter
)
Zentrale Servicegruppe
(Project Head
Fleckenstein, Bernhard
)
Major Research Instrumentation
Completed projects
Konfokales Laserscanning-Mikroskop
CRC/Transregios
Completed projects
Enhancement of HIV Env specific antibody responses by intrastructural help from heterologous T helper cells
(Project Head
Überla, Klaus
)
Establishment of long-term humoral memory against SARS-CoV-2 after vaccination versus infection
(Project Heads
Jäck, Hans-Martin
;
Winkler, Thomas
;
Überla, Klaus
)
Verbesserung der HIV Env Antikörperantwort durch intrastrukturelle Hilfe von heterologen T-Helfer-Zellen
(Project Head
Überla, Klaus
)
Research Training Groups
Current projects
GRK 2504: Novel antiviral approaches: from small molecules to immune intervention
(Spokesperson
Überla, Klaus
)
Completed projects
GRK 1045: Modulation of Host Cell Functions to Treat Viral and Bacterial Infections
(Spokesperson
Dittmer, Ulf
)
GRK 1071: Viruses of the Immune System
(Spokesperson
Fleckenstein, Bernhard
)
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