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Universitätsklinikum Freiburg
Department Innere Medizin
Klinik für Innere Medizin I - Hämatologie, Onkologie und Stammzelltransplantation

Address Hugstetter Straße 55
79106 Freiburg
Deutschland

GERiT This institution in GERiT

79106 Freiburg

Projects

Research Fellowships
- Completed projects
Research Grants
- Current projects
- Completed projects
Priority Programmes
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Immunregulation nach allogener hämatopoetischer Zelltransplantation
    (Applicant Zeiser, Robert )
Heisenberg Professorships
- Completed projects
  - Heisenberg Professorship in Hematology/Oncology "Immune-regulation and tumor immunology"
    (Applicant Zeiser, Robert )
Clinical Trials
- Current projects
  - A Randomized Controlled Trial on Pulmonary Metastasectomy vs. Medical Treatment Alone in Colorectal Cancer Patients with ≥ 3 Lung Metastases (PUCC-Trial)
    (Applicant Schmid, Severin )
  - Exploring the performance of a novel machine learning classifier for minimal-invasive CNS lymphoma diagnosis through ultrasensitive profiling of circulating tumor DNA from cerebrospinal fluid and blood plasma – a prospective oligo-center trial (DETECT_CNSL).
    (Applicant Scherer, Florian Paul )
- Completed projects
  - Prospective randomized multicenter phase III trial of decitabine and Venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy
    (Applicant Lübbert, Ph.D., Michael )
Research Units
- Current projects
  - Coordination Funds
    (Applicant Lübbert, Ph.D., Michael )
  - FOR 2033: The Hematopoietic Niches
    (Spokesperson Oostendorp, Robert A.J. )
  - FOR 2674: Aging-related epigenetic remodeling in acute myeloid leukemia
    (Spokesperson Lübbert, Ph.D., Michael )
  - FOR 5659: TARGET-MPN: TARgetinG disease pErsisTence and progression of MyeloProliferative Neoplasms (MPN)
    (Spokesperson Heidel, Florian )
  - Molecular mechanisms of epigenetic therapies
    (Applicants Goyal, Ph.D., Ashish ; Lübbert, Ph.D., Michael ; Plass, Christoph )
  - Targeting immune escape mechanisms to eliminate persisting MPN cells
    (Applicant Zeiser, Robert )
  - The DNA methylome as a therapeutic target in elderly patients with acute myeloid leukemia: Development of combination treatments
    (Applicants Becker, Heiko ; Lübbert, Ph.D., Michael )
- Completed projects
  - Dissecting the interaction of the PIM1/CXCR4 axis and Hedgehog signaling within the niche determing HSC mobilization and leukemic transformation
    (Applicants Dierks, Christine ; Duyster, Justus )
WBP Return Grant
- Current projects
  - Rückkehrstipendium
    (Applicant Wertheimer, Tobias )
Collaborative Research Centres
- Current projects
  - Impact of wild-type intestinal microbiome on impaired immune regulation during acute graft-versus-host disease
    (Project Heads Rosshart, Stephan Patrick ; Zeiser, Robert )
  - Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host disease
    (Project Heads Köhler, Natalie ; Zeiser, Robert )
  - S2: Preclinical Imaging and NMR Spectroscopy
    (Project Heads Reichardt, Wilfried ; Zeiser, Robert )
  - Serviceprojekt
    (Project Head Zeiser, Robert )
  - SFB 1479: Oncogene-driven immune escape (OncoEscape)
    (Spokesperson Zeiser, Robert )
  - Targeting MDM2-induced p53 downregulation to enhance anti-leukaemia immunity
    (Project Head Zeiser, Robert )
  - The role of oncogene-driven activation of the CMTM6 / PD-L1 axis in leukaemia immune escape
    (Project Head Köhler, Natalie )
  - The role of oncogene induced Oncostatin M in reprogramming the stem cell niche and promoting immune escape of leukaemia
    (Project Head Duyster, Justus )
- Completed projects
Major Research Instrumentation
- Completed projects
  - Durchflusszytometer
  - High Speed Cell Sorter
CRC/Transregios
- Current projects
  - The role of microglia during immunotherapy-induced neuroinflammation
    (Project Head Zeiser, Robert )
- Completed projects
  - The Role of Differentiation Status and Plasticity of the Lymphoma-initiating Cell in Pathogenesis of large Cell anaplastic Lymphoma in a conditional NPM-ALK Model
    (Project Heads Duyster, Justus ; Miething, Cornelius )
WBP Fellowship
- Current projects
  - Coevolution of tumor and microenvironment during colorectal cancer liver metastasis
    (Applicant Rettig, Andres )
- Completed projects
  - The role of GM-CSF in the modulation of anti-tumor immunity in myeloproliferative neoplasms.
    (Applicant Wertheimer, Tobias )
Independent Junior Research Groups
- Completed projects
  - Macrophage proliferation, the engine of plaque progression
    (Applicant Hilgendorf, Ingo )

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