Klinikum der Universität München
Campus Großhadern
Institut für Schlaganfall- und Demenzforschung (ISD)
Address
Feodor-Lynen-Straße 17
81377 München
Deutschland
GERiT
This institution in GERiT
81377 München
Projects
Research Fellowships
Completed projects
Freisetzung mitochondrialer Proteine nach fokaler zerebraler Ischämie
(Applicant
Plesnila, Nikolaus
)
Research Grants
Current projects
Functional characterization of the ASIC1a proteome
(Applicant
Gründer, Stefan
)
Modulation of microglial function by microbiota-derived metabolites in cerebral ischemia
(Applicant
Benakis, Corinne
)
Multidimensional interrogation of microvascular matrisome abnormalities in cerebral small vessel diseases
(Applicant
Dichgans, Martin
)
Role of oxidative stress for neuro-vascular function
(Applicant
Plesnila, Nikolaus
)
Role of SCARF1 in Arterial Inflammation
(Applicants
Asare, Yaw
;
Dichgans, Martin
)
Structural and functional basis of the regulatory role of MDL proteins in plant and human immunity
(Applicants
Bernhagen, Jürgen
;
Panstruga, Ralph
)
The MIF protein family in cardiac ischemia and heart failure: molecular mechanisms and translational avenues
(Applicants
Bernhagen, Jürgen
;
Stoppe, Christian
)
The “no-reflow” phenomenon revisited: Delayed microvascular occlusions as a novel therapeutic target for ischemic stroke
(Applicant
Khalin, Ph.D., Igor
)
Uncovering the role of rare and low-frequency mutations in stroke using a polygenic risk score informed approach – implications for risk prediction
(Applicants
Dichgans, Martin
;
Malik, Rainer
)
Completed projects
Assessing neurodegeneration throughout the entire brain at a single cell resolution after TBI in mice
(Applicant
Ertürk, Ali
)
Brain-invading T cells as regulators of microglial function in stroke
(Applicant
Benakis, Corinne
)
Charakterisierung eines dritten Gens für Familiäre Hemiplegische Migräne und Untersuchung von Genotyp-Phänotyp-Korrelationen bei FHM
(Applicant
Dichgans, Martin
)
Development of genetically encoded fluorescent K+ probes
(Applicants
Plesnila, Nikolaus
;
Rehberg, Markus
)
Die Rolle des inflammatorischen Zytokins MIF beim myokardialen Ischämie-Reperfusionsschaden: Interaktion mit der Nitrit-Signaltransduktion
(Applicant
Rassaf, Tienush
)
Dysregulated CD74 in macrophage-trophoblastic interactions and the pathogenesis of preeclampsia
(Applicant
Herse, Florian
)
Evaluation of a novel approach for in situ soft tissue engineering by external expansion
(Applicants
Bernhagen, Jürgen
;
Pallua, Norbert
)
Leukocyte interaction with immunological interfaces of the brain after stroke
(Applicant
Liesz, Arthur
)
Macrophage migration inhibitory factor (MIF) als Chemokin-artiger Mediator von Entzündungsprozessen bei der spontanen und akzelerierten Atherosklerose
(Applicant
Bernhagen, Jürgen
)
Molecular mechanisms of recessive and dominant mutations in the small vessel disease-related high temperature requirement protease HTRA1
(Applicants
Beaufort, Nathalie
;
Dichgans, Martin
)
Molekulare Mechanismen der Notch3-Aggregation in der Pathogenese von CADASIL
(Applicant
Dichgans, Martin
)
Molekulare Struktur- und Funktionsanalyse des Cytokins und Hormons Macrophage Migration Inhibitory Factor (MIF)
(Applicant
Bernhagen, Jürgen
)
Pathophysiology of familial hemiplegic migraine: analysis of a newly generated transgenic SCN1A mouse model
(Applicants
Freilinger, Tobias
;
Plesnila, Nikolaus
)
The Role of Macrophage Migration Inhibitory Factor (MIF) Family Proteins in Wound Repair and Obesity
(Applicants
Bernhagen, Jürgen
;
Kim, Bong-Sung
)
The role of MIF in myocardial ischemic preconditioning
(Applicants
Bernhagen, Jürgen
;
Stoppe, Christian
)
Untersuchung des klinischen Verlaufs von CADASIL und seiner bildgebenden Korrelate
(Applicant
Dichgans, Martin
)
Veränderungen der Mikrozirkulation nach aneurysmatischer Subarachnoidalblutung (SAB): Kinetik, Bedeutung und Identifikation von Mechanismen
(Applicant
Plesnila, Nikolaus
)
X-KINGDOM-MIF - Cross-kingdom analysis of macrophage migration inhibitory factor (MIF) functions
(Applicants
Bernhagen, Jürgen
;
Kogel, Karl-Heinz
;
Panstruga, Ralph
)
Clinical Research Units
Completed projects
Ausbau einer DNA-Bank für neurogenetische Erkrankungen
(Applicant
Gasser, Thomas
)
Charakterisierung eines dritten Gens für Familiäre Hemiplegische Migräne und Untersuchung von Genotyp-Phänotyp-Korrelationen bei FHM
(Applicant
Dichgans, Martin
)
Spezialambulanz für neurogenetische Erkrankungen
(Applicant
Gasser, Thomas
)
Emmy Noether Independent Junior Research Groups
Current projects
Deciphering the Role of Oligodendrocytes in the Pathogenesis of Alzheimer’s Disease
(Applicant
Jaekel, Sarah
)
Multi-omic characterization of the immune mechanisms driving human atheroprogression
(Applicant
Georgakis, Ph.D., Marios
)
Completed projects
Brain-released alarmins as mediators of immunological comorbidities after stroke
(Applicant
Liesz, Arthur
)
WBP Position
Current projects
An integrated platform for the single-cell transcriptomics-based identification of repurposable therapeutics in Alzheimer’s Disease (AD) using human iPSCs-derived 3D neuroimmune co-cultures
(Applicant
Carraro, Caterina
)
Serial Metabolomic Profiling to Inform on Novel Mechanisms and Biomarkers for Stroke
(Applicant
Vlegels, Naomi
)
The long-term consequences of stroke on systemic immunity
(Applicant
Simats, Ph.D., Alba
)
Research Units
Current projects
Chronic inflammasome activation in post-stroke recovery
(Applicants
Hornung, Veit
;
Liesz, Arthur
;
Schmidt-Pogoda, Antje
)
Coordination Funds
(Applicant
Liesz, Arthur
)
FOR 2879: ImmunoStroke: From immune cells to stroke recovery
(Spokesperson
Liesz, Arthur
)
Mechanisms of microglia-induced circuit remodeling in post-stroke recovery
(Applicants
Liesz, Arthur
;
Magnus, Tim
;
Misgeld, Thomas
)
Meningeal immune cell priming for stroke recovery
(Applicants
Benakis, Corinne
;
Meyer zu Hörste, Gerd
;
Minnerup, Jens
)
Microglia-PET as a surrogate marker for post-stroke neuroinflammation
(Applicants
Brendel, Matthias
;
Dichgans, Martin
;
Ziegler, Sibylle Ilse
)
Standardization of animal models and outcome parameters
(Applicants
Langhauser, Friederike
;
Llovera, Gemma
)
Completed projects
Strukturelle und funktionelle Charakterisierung der MIF/Chemokinrezeptor-Achse bei Atherosklerose und Myokardinfarkt
(Applicant
Bernhagen, Jürgen
)
Collaborative Research Centres
Current projects
Differential mechanisms of MIF proteins in atherosclerosis and selective peptide-based strategies for intervention
(Project Heads
Bernhagen, Jürgen
;
Kapurniotu, Aphrodite
)
Inflammation begets inflammation – impact of remote injuries on atherosclerosis progression
(Project Heads
Liesz, Arthur
;
Sager, Hendrik
)
Interactions of chemokines with heterologous effectors in atherosclerosis
(Project Heads
Bernhagen, Jürgen
;
Gabius, Hans-Joachim
;
von Hundelshausen, Philipp
;
Koenen, Ph.D., Rory R.
)
Mechanisms underlying the role of HDAC9 in atherosclerosis
(Project Heads
Asare, Yaw
;
Dichgans, Martin
;
Haffner, Christof
)
Completed projects
CXCR and CD74 receptor mechanisms of the cytokine MIF and their role in nephrotoxic nephritis
(Project Heads
Bernhagen, Jürgen
;
Ostendorf, Tammo
;
Weber, Christian
)
Functional Analysis and bichemical Characterization of the mutant notch3 Receptor; Generation of a transgenic Mouse Model für Cadasil
(Project Head
Dichgans, Martin
)
Major Research Instrumentation
Completed projects
3-Tesla-Magnetresonanztomograph
Konfokalmikroskop
Multiphotonenmikroskop mit FLIM-Modul
CRC/Transregios
Current projects
Disease-overarching mechanisms of Treg-CNS interaction
(Project Heads
Bittner, Stefan
;
Liesz, Arthur
)
Microbiota-induced intestinal Treg cells modulate neuroinflammation
(Project Heads
Benakis, Corinne
;
Regen, Tommy
)
Molecular checkpoints regulating the repair capacity of surviving oligodendrocytes in an inflammatory environment
(Project Heads
Jaekel, Sarah
;
Kerschensteiner, Martin
)
Multicellular interactions of microglia in the chronically inflamed brain after ischemic stroke
(Project Head
Liesz, Arthur
)
Completed projects
Targeting MIF family proteins in liver fibrosis: Mechanisms and translational approaches
(Project Heads
Bernhagen, Jürgen
;
Berres, Marie-Luise
)
WBP Fellowship
Completed projects
Elucidating the etiology of cryptogenic stroke with human genetics
(Applicant
Georgakis, Ph.D., Marios
)
Priority Programmes
Current projects
T cells as modulators of microglial reactivity in Alzheimer’s disease
(Applicants
Liesz, Arthur
;
Tahirovic, Ph.D., Sabina
)
International Research Training Groups
Completed projects
GRK 1508: Arterial Remodelling
(Spokesperson
Bernhagen, Jürgen
)
Clusters of Excellence
Completed projects
EXC 1010: Munich Cluster for Systems Neurology (SyNergy)
(Spokesperson
Haass, Christian
)
Clusters of Excellence (ExStra)
Current projects
EXC 2145: Munich Cluster for Systems Neurology (SyNergy)
(Spokespersons
Haass, Christian
;
Misgeld, Thomas
)
