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Universität zu Köln
Department für Biologie
Institut für Genetik

Address Zülpicher Straße 47a
50674 Köln
Deutschland

GERiT This institution in GERiT

50674 Köln

Projects

Priority Programmes
- Current projects
  - Coordination of proteostasis and mitochondrial intermembrane space protein import
    (Applicants Hoppe, Ph.D., Thorsten ; Riemer, Jan )
  - MFN2 role, origin and evolution in protein aggregation and mitochondrial import capacity
    (Applicants Escobar-Henriques, Mafalda ; Hofmann, Kay )
- Completed projects
Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
  - Coordination Funds
    (Applicant Vilchez, David )
  - Coordination of DNA damage response and aging by ubiquitin signaling
    (Applicant Hoppe, Ph.D., Thorsten )
  - FOR 2743: Mechanical Stress Protection
    (Spokesperson Höhfeld, Jörg )
  - FOR 5504: Physiological causes and consequences of genome instability
    (Spokesperson Schumacher, Björn )
  - FOR 5762: Cell Non-Autonomous Regulation of Organismal Proteostasis
    (Spokesperson Vilchez, David )
  - Regulation of neuronal proteostasis by the germline
    (Applicants Lee, Ph.D., Hyun Ju ; Vilchez, David )
  - Role of sensory perception in cell non-autonomous proteostasis signaling
    (Applicant Hoppe, Ph.D., Thorsten )
  - Stress-induced myosin folding and assembly mechanisms
    (Applicant Hoppe, Ph.D., Thorsten )
  - Z1 Platform for quantitative proteomics and data integration
    (Applicants Krüger, Marcus ; Vilchez, David )
- Completed projects
  - Analysis of cytoplasmic functions of the exon junction complex
    (Applicant Gehring, Niels H. )
  - Coordination of morphogenetic actions across the entire organism
    (Applicant Leptin, Ph.D., Maria )
  - FOR 885: Neuronal Protein Turnover
    (Spokesperson Glatzel, Markus )
  - RP1: Identification of ubiquitin-dependent pathways involved in neuron-specific protein degradation
    (Applicant Hoppe, Ph.D., Thorsten )
  - RP7: Investigation of novel mechanisms in degradation of aggregated neuroserpin
    (Applicants Glatzel, Markus ; Hoppe, Ph.D., Thorsten )
Heisenberg Fellowships
- Completed projects
  - Regulation and quality control of human mRNPs
    (Applicant Gehring, Niels H. )
  - The evolution of natural variation and molecular innovations in social insects
    (Applicant Hasselmann, Martin )
Heisenberg Professorships
- Completed projects
  - Mechanismen der Genexpression in Eukaryoten
    (Applicant Gehring, Niels H. )
Heisenberg Grants
- Completed projects
  - Mechanisms of Gene Expression in Eukaryotes
    (Applicant Gehring, Niels H. )
Emmy Noether Independent Junior Research Groups
- Current projects
  - ADP-ribosylation at the nuclear pore complex
    (Applicant Leidecker, Orsolya )
Collaborative Research Centres
- Current projects
  - Central Tasks
    (Project Head Pasparakis, Manolis )
  - Coordination of endoplasmic reticulum-associated fidelity machines
    (Project Head Hoppe, Ph.D., Thorsten )
  - Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach
    (Project Heads Garcia Sáez, Ana Jesús ; Pasparakis, Manolis )
  - Defining the interplay between RNA and protein toxicity in C9orf72-related amyotrophic lateral sclerosis (ALS)
    (Project Head Vilchez, David )
  - Desert transcriptomics: assessing the genetic basis of adaptation to aridity in desert dwellers
    (Project Heads Bechteler, Julia ; Quandt, Dietmar ; Wiehe, Thomas )
  - Genetically engineered mouse models for the study of cell death and its role in immunity and inflammation
    (Project Head Pasparakis, Manolis )
  - Impact of nonsense-mediated mRNA decay on gene expression fidelity
    (Project Head Gehring, Niels H. )
  - Inflammatory and necroptotic signaling in SCLC
    (Project Head Pasparakis, Manolis )
  - Integrated Research Training Group "mito-RTG"
    (Project Heads Dohmen, Jürgen ; Riemer, Jan )
  - Mechanisms of cell death-induced inflammation
    (Project Head Pasparakis, Manolis )
  - Research data management, analysis and bioinformatics support
    (Project Heads Hofmann, Kay ; von Karstedt, Silvia ; Wesner, Stefan )
  - SFB 1403: Cell Death in Immunity, Inflammation and Disease
    (Spokesperson Pasparakis, Manolis )
  - The evolution of regulated necrotic cell death
    (Project Head Hofmann, Kay )
  - Thrombospondin-1 and NF-κB signaling in ocular graft-versus-host disease (GVHD)
    (Project Heads Pasparakis, Manolis ; Steven, Philipp )
  - Ubiquitin-dependent coordination of mitochondrial-cytoplasmic quality control
    (Project Head Hoppe, Ph.D., Thorsten )
- Completed projects
  - Central animal facility: Generation, breeding and husbandry of mice including murine infection models
    (Project Heads Kastenmüller, Wolfgang ; Knolle, Percy Alexander ; Mahabir-Brenner, Esther ; Pasparakis, Manolis ; Utermöhlen, Olaf )
  - Characterization of an ancient cell death signaling module
    (Project Heads Hofmann, Kay ; Pasparakis, Manolis )
  - Earth-life evolution on short time scales
    (Project Head Wiehe, Thomas )
  - Epithelial TNFR1 signalling in skin homeostasis and inflammation
    (Project Head Pasparakis, Manolis )
  - Evolutionary innovations - a case study on chromatin insulators
    (Project Head Wiehe, Thomas )
  - Genetic interactions between tumors and their microenvironment
    (Project Head Uhlirova, Mirka )
  - Innate receptor signalling in host defence
    (Project Head Pasparakis, Manolis )
  - In vivo-Proteomik des IKK-Komplexes
    (Project Head Pasparakis, Manolis )
  - Multiple mechanisms controlling the SUMO modified state of proteins
    (Project Head Dohmen, Jürgen )
  - Neuronaler Proteinabbau
    (Project Head Hoppe, Ph.D., Thorsten )
  - Phosphotyrosine binding mediators of FGF signalling and cell junction remodelling
    (Project Head Leptin, Ph.D., Maria )
  - Protist evolution at the dry limit
    (Project Heads Arndt, Hartmut ; Wiehe, Thomas )
  - Role of mitochondria in the regulation of intestinal epithelial cell death and inflammation
    (Project Head Pasparakis, Manolis )
  - Role of SUMO-targeted ubiquitylation in the control of mitochondrial fission
    (Project Head Dohmen, Jürgen )
  - Substrate recruitment and ubiquitylation by E3 ligase complexes
    (Project Head Hoppe, Ph.D., Thorsten )
  - The genetic and cell biological control of gastrulation in Drosophila
    (Project Head Leptin, Ph.D., Maria )
  - The role of UPF1 phosphorylation during nonsense-mediated mRNA decay
    (Project Head Gehring, Niels H. )
Research Fellowships
- Completed projects
  - Untersuchungen zur Rolle von I-kappa-B Kinase (IKK) Untereinheiten in der Entstehung des Hepatozellulären Karzinoms, Verwendung von konditionellen Knockoutmäusen zur spezifischen Gendeletion von Ikk1, Ikk2 und Nemo in der Leber
    (Applicant Lüdde, Ph.D., Tom )
Major Research Instrumentation
- Completed projects
  - Konfokales Laserscanning-Mikroskop
  - Large-Particle Flow Cytometer
DIP Programme
- Completed projects
  - Challenging the ubiquitin proteolytic signal - Novel modes of modification and recognition
    (Applicants Glickman, Michael H. ; Hoppe, Ph.D., Thorsten )
Clinical Research Units
- Completed projects
  - KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia
    (Spokesperson Hallek, Michael )
  - Ubiquitin-dependent regulation of the DNA damage-induced apoptosis and relevance for the chemoresistance of refractory CLL
    (Applicants Hoppe, Ph.D., Thorsten ; Kashkar, Hamid )
CRC/Transregios
- Current projects
  - Evolutionary signatures in gene copy-number variation in Brassicaceae
    (Project Heads Rose, Laura ; Wiehe, Thomas )
  - Necroptosis in aortic aneurysm disease - significance of inflammation in MLKL dependent cell death
    (Project Heads Adam, Matti ; Garcia Sáez, Ana Jesús ; Pasparakis, Manolis )
Research Training Groups
- Current projects
  - GRK 2550: Dynamic regulation of cellular protein localization
    (Spokesperson Riemer, Jan )
- Completed projects
  - GRK 296: Genetics of Cellular Systems
    (Spokesperson Leptin, Ph.D., Maria )
  - GRK 2407: Inflammatory and cellular stress signaling: Switches to vascular dysfunction
    (Spokesperson Baldus, Stephan )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2030: CECAD - Excellent in Aging Research
    (Spokespersons Benzing, Thomas ; Hoppe, Ph.D., Thorsten ; Niessen, Carien )
Clusters of Excellence
- Completed projects
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases
    (Spokesperson Brüning, Jens Claus )

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