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Institution

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Charité - Universitätsmedizin Berlin
Campus Benjamin Franklin
Medizinische Klinik für Gastroenterologie,
Infektiologie und Rheumatologie

Address Hindenburgdamm 30
12200 Berlin
Deutschland

GERiT This institution in GERiT

12200 Berlin

Projects

Research Fellowships
- Completed projects
Research Grants
- Current projects
- Completed projects
Emmy Noether Independent Junior Research Groups
- Completed projects
  - A new function for Leptin: Evaluation of Leptin in experimental colitis in mice
    (Applicant Siegmund, Britta )
Research Units
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Chemokinvermittelte Transmigration durch das Sinusendothel der Leber: molekulare Mechanismen und therapeutische Zielstrukturen bei hepatischer Entzündung
    (Applicant Klugewitz, Katja )
Heisenberg Professorships
- Completed projects
  - Translationale Gastroenterologie - Chronisch entzündliche Darmerkrankungen
    (Applicant Siegmund, Britta )
Collaborative Research Centres
- Current projects
  - Hydrogel Properties on Intestinal Surfaces in Health and Disease
    (Project Heads Siegmund, Britta ; Weinhart, Marie )
  - Inflammatory Activity and Targeting of the Extracellular Matrix in Inflammatory Bowel Diseases
    (Project Heads Kühl, Anja A. ; Siegmund, Britta )
  - In vitro and in vivo Hydrogel Model Systems Core Unit
    (Project Heads Duerr, Julia ; Mall, Marcus ; Siegmund, Britta ; Weinhart, Marie )
- Completed projects
  - Administrative Project of the Collaborative Research Centre
    (Project Heads Siegmund, Britta ; Zeitz, Martin )
  - Antigen-specific regulatory T-cells for cellular therapies
    (Project Heads Sieper, Joachim ; Thiel, Andreas )
  - Cellular approaches for the treatment of intestinal Graft-versus-Host disease and inflammatory bowel disease
    (Project Heads Maul, Jochen ; Rieger, Kathrin ; Uharek, Lutz )
  - Characterisation of human peripheral and intestinal T cell responses after mucosal antigen exposition: Induction of tolerance vs. immunity
    (Project Heads Dörner, Thomas ; Ullrich, Reiner )
  - Cldn10a in kidney injury susceptibility
    (Project Heads Günzel, Dorothee ; Schmidt-Ott, Kai )
  - Development of systematic morpholgical methods for the evaluation of mucosal inflammations and the in-situ detection of defined cell populations
    (Project Heads Kühl, Anja A. ; Schulzke, Jörg-Dieter ; Siegmund, Britta ; Zeitz, Martin )
  - Einfluß von Kollagen VI und Kollagen XIV auf Zellproliferation, Apoptose und Differenzierung
    (Project Head Somasundaram, Rajan )
  - Funktion von CD2 für die intestinale T-Zellaktivierung und deren Modulation bei Colitis
    (Project Head Hoffmann, Jörg Carl )
  - Identification of T cell epitopes relevant for inflammatory bowel diseases and their rheumatic manifestations
    (Project Heads Duchmann, Rainer ; Sieper, Joachim ; Thiel, Andreas )
  - Identifizierung HLA B27 -restringierter Peptide von Bakterien, die reaktive Arthritis auslösen, und ihre Relevanz für die Immunpathologie der Spondylarthropathien
    (Project Head Sieper, Joachim )
  - Immunmodulatorische Funktion von CD44v7 bei der Induktion von antigenspezifischer Toleranz
    (Project Head Wittig, Bianca )
  - Induktion und Stabilisierung des IL-10 Gedächtnisses von Tr1-Zellen für zelluläre immunregulatorische Therapien
    (Project Heads Radbruch, Andreas ; Sieper, Joachim ; Thiel, Andreas )
  - Integrated Research Training Group IMMUCO
    (Project Heads Klugewitz, Katja ; Moos, Verena ; Radbruch, Andreas ; Zeitz, Martin )
  - Mesenteric adipose tissue - regulatory function in intestinal inflammation
    (Project Head Siegmund, Britta )
  - Modulation of the T cell dependent immune defence against Helicobacter pylori under the influence of cholesterol
    (Project Heads Aebischer, Anton ; Ignatius, Ralf ; Meyer, Thomas F. ; Schneider, Thomas )
  - Morbus Whipple - Investigation of interactions of T cells and antigen-presenting cells
    (Project Heads Moos, Verena ; Schneider, Thomas )
  - Paracellular intestinal barrier effects of probiotics and feed additives
    (Project Heads Fromm, Michael ; Schulzke, Jörg-Dieter )
  - SFB 633: Induction and Modulation of T cell Mediated Immune Responses in the Gastrointestinal Tract
    (Spokespersons Siegmund, Britta ; Zeitz, Martin )
  - The liver as a part of the mucosal immune system: induction of oral tolerance and of regulatory CD4+ T cells
    (Project Head Klugewitz, Katja )
  - Untersuchungen zur Funktion intestinaler Immunzellen in humanen peyerschen Plaques und muskosalen Lymphfollikeln
    (Project Heads Ullrich, Reiner ; Zeitz, Martin )
Clinical Research Units
- Current projects
  - impact of microbiota for induction of pathogenic, brain-specific antibodies
    (Applicants Kruglov, Andrey A. ; Siegmund, Britta )
  - KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
    (Spokesperson Endres, Matthias )
- Completed projects
Clinical Trials
- Completed projects
  - Diagnostic accuracy of recently proposed criteria for inflammatory back pain (IBP) in suspected ankylosing spondylitis (AS) and early axial spondyloarthritis (axial SpA)
    (Applicant Sieper, Joachim )
  - Prospective, double-blind diagnostic study of confocal laser endomicroscopy (CLE) for wheat sensitivity (WS) in patients with irritable bowel syndrome
    (Applicant Bojarski, Christian )
Major Research Instrumentation
- Completed projects
Priority Programmes
- Completed projects
CRC/Transregios
- Current projects
- Completed projects
  - Epigenetic Control of the Transcription of Homing Receptors
    (Project Heads Hamann, Alf ; Syrbe, Uta )
WBP Fellowship
- Current projects
  - Site-specific intestinal macrophage subtyping in health & inflammatory bowel diseases
    (Applicant Gutwein, Catharina )
Research Training Groups
- Current projects
  - GRK 2318: Tight junctions and their proteins: molecular features and actions in health and disease
    (Spokesperson Schulzke, Jörg-Dieter )
- Completed projects
  - GRK 276: Signal Recognition and Transduction
    (Spokesperson Wiedenmann, Bertram )

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