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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für Innere Medizin
I. Medizinische Klinik und Poliklinik
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
CNS antigen-specific CD4+ T cells as modulators of inflammation and regeneration in stroke
(Applicants
Carambia, Antonella
;
Gelderblom, Mathias
)
Composition and functional heterogeneity of naïve-like T cells in primary sclerosing cholangitis (PSC)
(Applicant
Schwinge, Dorothee
)
Consequences of Hepatitis B virus DNA integrations for the host and the virus using a new mouse model
(Applicant
Allweiss, Lena
)
Developmental trajectory and function of Th10 cells in IBD
(Applicants
Gagliani, Ph.D., Nicola
;
Huber, Samuel
)
iDfellows: Hamburg Clinician Scientist Programme in Infectious Diseases
(Applicant
Lohse, Ansgar W.
)
Impact of the apoptotic cell identity on macrophage function: A novel approach for the re-establishment of liver homeostasis upon damage
(Applicant
Bosurgi, Ph.D., Lidia
)
Influence of the microbiota on intestinal dendritic cells and its impact on Inflammatory Bowel Disease
(Applicant
Velasquez, Ph.D., Lis Noelia
)
LAM Cell-based therapy of inflammatory metabolic diseases
(Applicant
Adlung, Lorenz
)
The role of liquid biopsy in identifying circulating molecular predictors of response or resistance to systemic therapy in hepatocellular carcinoma
(Applicant
von Felden, Johann
)
The role of miR-122 in autoimmune liver diseases
(Applicant
Herkel, Johannes
)
Completed projects
Analysis of the molecular and functional heterogeneity of Foxp3Neg IL-10-producing T cells
(Applicants
Gagliani, Ph.D., Nicola
;
Huber, Samuel
)
Bedeutung des fibrotischen Mikromilieus für die Entstehung des Hepatozellulären Karzinoms
(Applicant
Kluwe, Johannes
)
Charakterisierung der adaptiven Immunantwort gegen das SepSecS Molekül bei autoimmuner Hepatitis
(Applicant
Weiler-Normann, Christina
)
Charakterisierung genetischer Veränderungen im Rahmen der malignen Transformation von Telomerase-immortalisierten humanen Hepatozyten
(Applicant
Wege, Henning
)
Charakterisierung Hämoxygenase-1-basierter Therapieoptionen bei chronischer Hepatitis C Virus Infektion
(Applicant
Sass, Gabriele
)
Charakterisierung Hepatitis C Virus spezifischer CD4+ T Helfer Zell Antworten
(Applicant
Schulze zur Wiesch, Julian
)
Control of pro-inflammatory TH17 cells in the small intestine
(Applicant
Huber, Samuel
)
Die Bedeutung des CCK2-Rezeptors und seines Liganden Gastrin für C-Zellen, Calcitonin-Genexpression und Knochenstoffwechsel
(Applicant
Bläker, Michael
)
Die Rolle von Transforming growth factor-ß1 (TGF-ß1) und Platelet-derived growth factor (PDGF) im Rahmen der Leberfibrogenese: Studie an transgenen Mausmodellen
(Applicant
Lohse, Ansgar W.
)
Functional characterization of Gonadotropin Releasing Hormone Receptor (GnRH-R) in Non Hodgkin´s Lymphoma (NHL) and Urothelial Carcinoma- a novel therapeutic target
(Applicant
von Amsberg, Gunhild
)
Hepatozytenabhängige Mechanismen des T-Zellversagens bei chronischer Virushepatitis
(Applicant
Wiegard, Christiane
)
Human Natural Killer T cells Type I and Type II and their Role in Inflammatory Liver Disease such as Autoimmune Hepatitis
(Applicant
Arrenberg, Philomena
)
Lysosomale Lipase: Untersuchungen zur Struktur und Funktion, zur Gentherapie der Enzymdefizienz und zur Rolle des Enzyms in der Pathogenese der Arteriosklerose
(Applicant
Ameis, Detlev
)
Mechanismen der Asthmaresistenz durch regulatorische T-Zellen und TGFß1
(Applicant
Schramm, Christoph
)
Molecular pathogenesis and signaling pathways: identification of therapeutic targets in primary sclerosing cholangitis (PSC)
(Applicant
Schramm, Christoph
)
Origin and function of the endogenous danger signal HMGB1 in the inflammatory response following infectious and immunological liver injury.
(Applicant
Hübener, Peter
)
Protective function of PDGFR-alpha in intestinal Inflammation
(Applicant
Manthey, Carolin Friederike
)
Psychosoziale Risikofaktoren bei der Entstehung des postinfektiösen Reizdarmsyndroms: eine prospektive Kohortenstudie
(Applicant
Löwe, Bernd
)
Regulation of immune cell populations and immune pathways by sex hormones
(Applicant
Altfeld, Marcus
)
Regulation of the activation status in T effector cells in blood and livers of patients with autoimmune hepatitis (AIH)
(Applicant
Sebode, Marcial
)
Regulatorische T-Zellen in der Therapie entzündlicher Lebererkrankungen
(Applicant
Schramm, Christoph
)
Role of the arylhydrocarbon receptor in hepatic immune regulation
(Applicant
Carambia, Antonella
)
Rolle nicht-parenchymatöser Leberzellen bei hepatischen Immunreaktionen
(Applicant
Herkel, Johannes
)
Tissue specific control of CD4+ T cells via IL-10 signaling
(Applicant
Huber, Samuel
)
Transmission Networks of Extended-spectrum beta-lactamase producing-Enterobacteriaceae in communities and hospitals in rural sub-Sahara Africa
(Applicant
Eibach, Daniel
)
Transplantation von Leberzellen für die Therapie Leber-basierter metabolischer Erkrankungen
(Applicant
Benten, Daniel
)
Untersuchung der Virus-Wirts Interaktionen im Laufe einer chronischen Koinfektion mit Hepatitis Delta und Hepatitis B Viren in uPA Mäusen
(Applicants
Dandri-Petersen, Maura
;
Lütgehetmann, Marc
)
Use of the upa chimeric mouse model for the study of hepadnaviral repliction and stability of cccDNA molecules
(Applicant
Petersen, Jörg
)
Research Fellowships
Completed projects
Analyse und Modulation CD4+CD25+Foxp3+ regulatorischer und IL-17 produzierender T-Zellen in murinen Colitismodellen anhand Foxp3-RFP/IL-17-GFP Reporter Mäuse
(Applicant
Huber, Samuel
)
Analysis of the interaction of Fusobacterium nucleatum and CEACAM1 and its impact on antitumor immunity
(Applicant
Galaski, Johanna
)
Characterization of genes involved in chromatin remodeling complexes and their functional role in hepatocarcinogenesis.
(Applicant
Schulze, Kornelius
)
DAMPs in hepatic fibrogenesis and carcinogenesis.
(Applicant
Hübener, Peter
)
Die Rolle des Tumorstromas bei hepatozellulären Karzinomen: Matrix, Fibroblasten und Makrophagen als neue Therapieziele?
(Applicant
Schrader, Jörg
)
Die Rolle von natürlichen Killer T Zellen in entzündlicher Lebererkrankung: Untersuchung des Schutzmechanismus vor Concanavalin-A induzierter Hepatitis
(Applicant
Arrenberg, Philomena
)
Funktion von IL-17 in Giardiasis: Identifizierung von IL-17-produzierenden Zellen, Induktionsmechanismen und Funktion von IL-17 im adaptiven Immunsystem in Giardiasis
(Applicant
Manthey, Carolin Friederike
)
Kupffer cell dysfunction in liver cirrhosis leads to uncontrolled infection
(Applicant
Peiseler, Moritz
)
"Liquid Biopsy" in Liver Cancer
(Applicant
von Felden, Johann
)
Mechanisms of maintenance CD8+ T cell memory responses (Memory Inflation) upon vaccination
(Applicant
Zinser, Madeleine Elisabeth
)
NLRP10 and adipocyte caspase-1 signalling protect against onset and progression of non-alcoholic fatty liver disease
(Applicant
Liwinski, Timur
)
Regulation der Leberrepopulation durch transplantierte Hepatozyten: Studien zu Zellinteraktionen mit Hepatischen Sternzellen
(Applicant
Benten, Daniel
)
The mycobiome and clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation.
(Applicant
Rolling, Thierry
)
Heisenberg Professorships
Completed projects
Intestinal Immune Regulation
(Applicant
Huber, Samuel
)
Virus Hepatitis
(Applicant
Dandri-Petersen, Maura
)
Clinical Research Units
Completed projects
Analysis of the connection between inflammatory bowel disease and primary sclerosing cholangitis (PSC)
(Applicant
Huber, Samuel
)
Central Project
(Applicant
Lohse, Ansgar W.
)
Coordination Funds
(Applicant
Schramm, Christoph
)
Innate immune cells in the pathogenesis of PSC
(Applicants
Altfeld, Marcus
;
Herkel, Johannes
)
KFO 306: Primär Sklerosierende Cholangitis
(Spokesperson
Lohse, Ansgar W.
)
Neutrophil Extracellular Traps in the pathogenesis of PSC
(Applicant
Renné, Thomas
)
The intestinal and biliary microbiome in Primary Sclerosing Cholangitis (PSC)
(Applicants
Franke, Andre
;
Schramm, Christoph
)
Research Units
Current projects
Fatigue in Primary Biliary Cholangitis: Factors Associated With Severity and Persistence as Future Therapeutic Targets (RU SOMACROSS)
(Applicants
Schramm, Christoph
;
Toussaint, Ph.D., Anne
)
FOR 5068: Sex differences in immunity
(Spokesperson
Altfeld, Marcus
)
FOR 5211: Persistent Somatic Symptoms Across Diseases: From Risk Factors to Modification
(Spokesperson
Löwe, Bernd
)
FOR 5775: Macrophage Niche Network Dynamics - Defining macrophages as choreographers of tissue development and function
(Spokesperson
Mass, Elvira
)
Persistence of Gastrointestinal Symptoms in Irritable Bowel Syndrome and Ulcerative Colitis: From Risk Factors to Modification (RU SOMACROSS)
(Applicants
Lohse, Ansgar W.
;
Löwe, Bernd
)
The role of androgens in autoimmune liver diseases
(Applicant
Schramm, Christoph
)
The role of androgens in autoimmune liver diseases
(Applicants
Schramm, Christoph
;
Schwinge, Dorothee
)
Unravelling the role of IL-23 secretion by efferocytic macrophages in maintaining and reestablishing intestinal homeostasis
(Applicant
Bosurgi, Ph.D., Lidia
)
Heisenberg Grants
Completed projects
Intestinal Immune Regulation
(Applicant
Huber, Samuel
)
Collaborative Research Centres
Current projects
Academy for translational liver immunology
(Project Heads
Lohse, Ansgar W.
;
Schwinge, Dorothee
)
Adenine nucleotide-modulated T cell differentiation and effector functions
(Project Heads
Huber, Samuel
;
Mittrücker, Hans-Willi
)
Central data- and biobank
(Project Heads
Sebode, Marcial
;
Ückert, Frank
)
Central tasks of the collaborative research centre
(Project Head
Schramm, Christoph
)
Dictating hepatic immune responses through bile acid-scavenging macrophages
(Project Heads
Bosurgi, Ph.D., Lidia
;
Worthmann, Anna
)
Humanized mice to study the zoonotic potential and pathophysiology of hepatotropic emerging pathogens
(Project Heads
Dandri, Maura
;
Rodriguez, Estefania
)
Integrated Research Training Group “Understanding emerging and re-emerging viruses”
(Project Heads
Dandri, Maura
;
Schulze zur Wiesch, Julian
)
Intestinal inflammation modulates liver immune responses
(Project Heads
Huber, Samuel
;
Kempski, Jan
)
Multidimensional analysis of protective and damaging adaptive immune responses in emerging viral infections
(Project Heads
Binder, Ph.D., Mascha
;
Schulze zur Wiesch, Julian
)
Protective early response patterns of innate cellular immune crosstalk in hemorrhagic fever virus infection
(Project Head
Hölzemer, Angelique
)
Public relations within the CRC “Emerging Viruses”
(Project Heads
Addo, Marylyn Martina
;
Lohse, Ansgar W.
)
Role of the ectonucleotidases CD39 and CD73 in immune responses to human viral infections
(Project Heads
Haag, Friedrich
;
Schulze zur Wiesch, Julian
)
SFB 1700: Immune regulation in the liver: from homeostasis to disease
(Spokesperson
Schramm, Christoph
)
Spatial decoding of hepatic microenvironments to decipher, diagnose and stratify autoim-mune hepatitis
(Project Heads
Puelles, Ph.D., Victor G.
;
Sebode, Marcial
;
Zimmermann, Marina
)
Targeting Th17 cell adaptation in renal autoimmune diseases
(Project Heads
Huber, Samuel
;
Krebs, Christian
)
T cells and cholangiocytes: an interaction that governs portal immune regulation and determines biliary inflammation
(Project Head
Schwinge, Dorothee
)
The biliary mucosal interface in hepatic immune regulation
(Project Head
Schramm, Christoph
)
The role of infected hepatocytes in regulating intrahepatic immunity
(Project Head
Dandri, Maura
)
The role of short expressed peptides and cell type composition in autoimmune liver inflamma-tion
(Project Heads
Hübner, Norbert
;
Schramm, Christoph
)
The role of TNF in the regulation of hepatic autoimmunity
(Project Heads
Adlung, Lorenz
;
Herkel, Johannes
)
The tolerogenic microenvironment in the liver facilitates metastasis formation
(Project Head
Giannou, Ph.D., Anastasios
)
Using functional genomics to decipher the impact of polymorphisms in the IL2RA locus and other primary sclerosing cholangitis risk loci
(Project Heads
Ellinghaus, Ph.D., David
;
Huber, Samuel
)
X-ray Fluorescence Imaging (XFI) of immune cells and soluble molecules in the liver
(Project Heads
Bosurgi, Ph.D., Lidia
;
Feliu, Neus
;
Grüner, Florian
)
Completed projects
Central tasks
(Project Head
Lohse, Ansgar W.
)
Characterization of functional interactions between inflammatory and oncogene-permissive pathways in hepatocarcinogenesis
(Project Head
Wege, Henning
)
Die rolle von SLA/LP und anderen kranheitsspezifischen Autoantigenen in der Pathogenese der autoimmunen Hepatitis
(Project Head
Herkel, Johannes
)
(Dys)-regulation of the cellular HCV-specific immune response
(Project Head
Schulze zur Wiesch, Julian
)
From apoptotic cell sensing to an innate memory response: a new aspect of Kupffer cell function
(Project Head
Bosurgi, Ph.D., Lidia
)
Harnessing hepatic tolerance mechanisms for antigen-specific treatment of autoimmune and allergic diseases
(Project Heads
Carambia, Antonella
;
Heeren, Ph.D., Jörg
;
Herkel, Johannes
)
Hepatitis D Virus induced pathogenesis and interaction with the immune system
(Project Heads
Dandri-Petersen, Maura
;
Lütgehetmann, Marc
)
Hepatocellular Carcinoma - Analysis of malignant transformation by retroviral gene transfer
(Project Heads
Benten, Daniel
;
Fehse, Boris
)
Hepatocyte-dependent mechanisms of T cell exhaustion in chronic viral hepatitis
(Project Heads
Oxenius, Annette
;
Wiegard, Christiane
)
IL-22 and IL-22BP in liver regeneration and carcinogenesis
(Project Head
Huber, Samuel
)
Induction and breaking of immune tolerance in the liver
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
Influence of hepatic lipid profiles on inflammation, fibrogenesis and carcinogenesis in the liver
(Project Head
Kluwe, Johannes
)
In vivo Funktion der Lysosomalen Lipase in transgenen und homozygot defizienten Mäusen
(Project Head
Ameis, Detlev
)
Mechanisms underlying and consequences of hepatic and intestinal manifestations of COVID-19
(Project Heads
Altfeld, Marcus
;
Huber, Samuel
)
Molecular mechanisms of hepatitis B virus persistence in chronically infected human chimeric mice
(Project Head
Dandri-Petersen, Maura
)
Phenotype and function of CD4+ T lymphocytes in autoimmune hepatitis
(Project Head
Weiler-Normann, Christina
)
Public Relations Work within the Collaborative Research Centre 841
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
Regulatory T cells and TH17 cells in experimental cholangitis
(Project Head
Schramm, Christoph
)
Role of the aryl hydrocarbon receptor in hepatic immune regulation
(Project Head
Carambia, Antonella
)
Rolle der Antigen-Präsentation in der Leber für die Viruspersistenz
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
(Spokesperson
Lohse, Ansgar W.
)
Toleranzentstehung und Toleranzdurchbrechung in der Leber
(Project Heads
Kanzler, Stephan
;
Lohse, Ansgar W.
)
Clinical Trials
Current projects
Radiofrequency ablation via catheter and transpapillary access in patients with cholangiocarcinoma (ACTICCA-2)
(Applicant
Wege, Henning
)
WBP Fellowship
Current projects
Ectopic Lymphoid Structures – reducing the spatio-temporal unit to provide effective local immunity by TRM in non-lymphoid tissues?
(Applicant
Krause, Jenny
)
Navigating the Liver: Spatiotemporal Regulation of CD4+ T Cell Migration and Function in Hepatocyte-Targeted Immunity
(Applicant
Steinmann, Silja
)
Roles of innate and memory NK cell responses in viral clearance and severe dengue pathogenesis in children.
(Applicant
Hermanussen, Lennart
)
The role of microbiota-driven T-cell immunity for intestinal inflammation in alcohol-associated liver disease
(Applicant
Harberts, Aenne
)
Completed projects
Analysis of T cell receptor heterogeneity in healthy individuals and inflammatory bowel disease and its interaction with microbial composition
(Applicant
Ergen-Behr, Can
)
Deciphering the developmental requirements of CD4+ tissue-resident memory T cells
(Applicant
Poch, Tobias
)
The role of intrahepatic regulatory T cells in immunotherapy of liver cancer
(Applicant
Kocheise, Lorenz
)
Major Research Instrumentation
Completed projects
5-Laser Flow cytometer
CRC/Transregios
Current projects
Intestinal metabolites and their impact on thermogenic responses by brown and white adipose tissues
(Project Heads
Heeren, Ph.D., Jörg
;
Schwinge, Dorothee
)
Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages
(Project Heads
Bosurgi, Ph.D., Lidia
;
Worthmann, Anna
)
Understanding and targeting the hepatic stellate cell-Kupffer cell niche in MASLD and MASH fibrosis
(Project Head
Peiseler, Moritz
)
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