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Institution
Klinikum der Universität München
Campus Innenstadt
Kinderklinik und Kinderpoliklinik im
Dr. von Haunerschen Kinderspital
Address
Lindwurmstraße 4
80337 München
Deutschland
GERiT
This institution in GERiT
80337 München
Projects
Research Fellowships
Completed projects
Analyse der Immunantwort der NKT Lymphozyten auf die EBV-Infektion vor dem Hintergrund der primären Immundefekte XLP-1 und XLP-2 zur molekularbiologischen Definition weiterer XLP-Entitäten
(Applicant
Hauck, Ph.D., Fabian Harald
)
Characterization of the molecular makeup of the hematopoietic stem cell (HSC) niche and its signals that support HSC homing, self-renewal, proliferation and engraftment in vivo in the zebrafish model
(Applicant
Binder, Vera
)
Characterizing Functional Genetic Variants Linking Immunity and Schizophrenia
(Applicant
Kim-Hellmuth, Sarah
)
Der Einfluss des angeborenen Immunsystems auf die erworbene Immunantwort im Neugeborenenalter in Abhängigkeit vom Vorliegen einer mütterlichen Atopie
(Applicant
Schaub, Bianca
)
Die Rolle der T-Zell-Aktivierung unter besonderer Berücksichtigung des Transkriptionsfaktors NF kappa B bei frühkindlichem Asthma bronchiale
(Applicant
Schröter, Christian
)
Functional analysis of a new genetic variant suspected to cause a novel form of primary immunodeficiency featuring frequent respiratory infections, a susceptibility to herpesviral infection and lymphoid malignancy in three individuals.
(Applicant
Gothe, Ph.D., Florian
)
Induktion und Modulation der Apoptose im Tiermodell der obstruktiven Uropathie
(Applicant
Lange-Sperandio, Bärbel
)
Potenzierung der neurogenen Inflammation in den Atemwegen durch Adenoviren-Vektoren
(Applicant
Beer-Wedde, Katrin D.
)
XIAP Deficiency and Intestinal Inflammation: Study of an Orphan Disease and Pathways relevant for Inflammatory Bowel Disease
(Applicant
Schwerd, Tobias
)
Clinical Research Units
Completed projects
Entwicklung gentherapeutischer Strategien zur Behandlung des Wiskott-Aldrich- Syndroms
(Applicant
Klein, Christoph
)
Genetik der kongenitalen Neutropenie
(Applicant
Klein, Christoph
)
KFO 110: Stem Cell Transplantation and Immunmodulation - Development of Molecular Therapeutic Strategies in Pediatrics
(Spokesperson
Welte, Karl
)
Klinische, genetische und immunologische Charakterisierung monogener Autoimmunerkrankungen bei Kindern
(Applicant
Klein, Christoph
)
Zentrale Verwaltungskosten
(Applicant
Klein, Christoph
)
Research Grants
Current projects
Decoding the role of RIPK1 in human immunity and intestinal inflammation - Molecular insights from children with monogenic RIPK1 deficiency
(Applicant
Kotlarz, Daniel
)
Disrupting spliceosome-licensed oncogene collaboration networks for precision cancer therapy
(Applicants
Braun, Christian Joerg
;
Schneider, Günter
)
Multinational study on rural environmental protection for childhood asthma – a central role for dendritic and regulatory B-cells during immune maturation
(Applicant
Schaub, Bianca
)
Rare lung diseases in children: phenotyping, genetics, course and disease burden
(Applicant
Griese, Matthias
)
Role of pro- and anti-inflammatory NF-κB and MAPK signaling of innate dendritic cells during asthma development in childhood and its modulation through farm environmental exposure
(Applicant
Schaub, Bianca
)
Role of steroid hormone differentiation during adolescence in metabolism and cardiometabolic health
(Applicants
Harris, Carla
;
Standl, Ph.D., Marie
)
Structural variants induced by chemotherapy in leukemia cells
(Applicants
Jeremias, Ph.D., Irmela
;
Korbel, Jan
)
Completed projects
3-Methylcrontonyl-CoA: Carboxylase Mangel Charakterisierung der Variabilität von Phänotyp und Genotyp
(Applicant
Röschinger, Wulf
)
Components of distinct rural environments confer asthma protection in childhood via A20-mediated immune effects in dendritic cells on regulatory T cells
(Applicant
Schaub, Bianca
)
Das Immunsystem des Neugeborenen: Charakterisierung des Phänotyps und Funktion von T Zellen im Nabelschnurblut im Rahmen von Endotoxinstimulation
(Applicant
Schaub, Bianca
)
Der Einfluss von probiotischen Bakterien auf die orale Mikroflora sowie den oralen/dentalen Biofilm
(Applicant
Arweiler, Nicole
)
Der Na-K-2Cl-Kotransporter in der perinatalen Lunge, transepithelialer Elektrolyttransport während der Lungenentwicklung
(Applicant
Flemmer, Andreas W.
)
Die Wirkung von TRAIL auf primäre Leukämiezellen und leukämische Stammzellen
(Applicant
Jeremias, Ph.D., Irmela
)
Environmental dissemination and accumulation of antibiotic pharmazeuticals, pathogens, and resistance determinants as caused by wastewater irrigation
(Applicants
Grohmann, Elisabeth
;
Siemens, Jan
)
Funktionelle Charakterisierung der humanen Gene und Proteine der frühen peroxisomalen Biogenese PEX3 und PEX19
(Applicant
Muntau, Ania Carolina
)
Induktion und Modulation von Entzündungsprozessen im neonatalen Tiermodell der obstruktiven Uropathie
(Applicant
Lange-Sperandio, Bärbel
)
Inflammation und Regeneration im neonatalen Tiermodell der obstruktiven Uropathie
(Applicant
Lange-Sperandio, Bärbel
)
Interstitial lung diseases (ILD) due to disturbed processing and function of the lipid transporter ABCA3 as a result of mutations in the ABCA3 gene
(Applicant
Griese, Matthias
)
Mechanisms of action and therapeutic potential of AHR and DRD5 receptors in Acute Myeloid Leukemia with MLL-fusion gene
(Applicant
Fleischmann, Katrin Kristina
)
Molecular and pharmacological inhibition of the t(4;11) fusion proteins MLL-AF4 and AF4-MLL
(Applicant
Marschalek, Rolf
)
Molekulare Auswirkungen von Gendefekten im Surfactantsyntheseapparat von Typ II Pneumozyten bei interstitiellen Lungenerkrankungen (ILD)
(Applicant
Griese, Matthias
)
Multi-centre analysis of immune-regulatory mechanisms that protect from childhood asthma in distinct rural environments
(Applicant
Schaub, Bianca
)
Novel strategies for personalized treatment of lung cancer using H19 gene regulatory sequences combined with targeted nucleic acid delivery
(Applicants
Klein, Christoph
;
Rudolph, Carsten
)
Querschnittsstudie zum Zusammenhang zwischen der Fettsäurenzusammensetzung von Serumlipiden, dem Fettverzehr und der Prävalenz bronchialer Hyperreaktivität, allergischer Sensibilisierung und atopischer Manifestationen bei Erwachsenen
(Applicant
Koletzko, Berthold V.
)
SOLAR III: Asthma and allergies from school age up to working life - analyses of occupational exposures and transgenerational effects over three generations. 20-years Follow-up of the ISAAC Phase II Study in Germany.
(Applicants
Radon, Katja
;
Vogelberg, Christian
)
Therapie der neonatalen Lungenhypoplasie durch tracheale Okklusion und / oder Perlurcarbon am Kaninchenmodell der kongenitalen Zwerchfellhernie
(Applicant
Flemmer, Andreas W.
)
Unraveling the immunological and microbial mechanisms of hay fever protection by multi-omics data integration
(Applicant
Pagani, Ph.D., Giulia
)
Unraveling the molecular pathophysiological landscape in primary immunodeficiencies to improve personalized medicine approaches.
(Applicant
Grimbacher, Bodo
)
Untersuchungen zum in vivo Stoffwechsel ungesättigter Fettsäuren mit stabilen Isotopen
(Applicant
Koletzko, Berthold V.
)
Uromodulin and Inflammation in Neonatal Obstructive Nephropathy
(Applicant
Lange-Sperandio, Bärbel
)
Heisenberg Professorships
Completed projects
Environment and development of immunological tolerance with the focus on the development of allergic diseases
(Applicant
Schaub, Bianca
)
Independent Junior Research Groups
Current projects
Deciphering the genetic basis of human immune response variation
(Applicant
Kim-Hellmuth, Sarah
)
Heisenberg Grants
Current projects
Environment and development of immunological tolerance with the focus on the development of allergic diseases
(Applicant
Schaub, Bianca
)
Reinhart Koselleck Projects
Current projects
Identifying novel targeted therapies for cancer using CRISPR/Cas9 dropout screens in PDX models in vivo
(Applicant
Jeremias, Ph.D., Irmela
)
Collaborative Research Centres
Current projects
Deciphering the role of Cyclin-T1 in human immune cell plasticity – Insights from children with inflammatory bowel disease
(Project Heads
Klein, Christoph
;
Kotlarz, Daniel
)
Impact of exclusive enteral nutrition on microbiome signatures and function in pediatric Crohn’s disease
(Project Heads
Haller, Dirk
;
Schwerd, Tobias
)
Completed projects
Clinical and Functional Characterization of the Genetic Basis of Chronic Viral Infections in Humans
(Project Head
Klein, Christoph
)
Evolution of patient derived xenograft acute myeloid leukaemia subclones in a preclinical mouse model
(Project Head
Jeremias, Ph.D., Irmela
)
Genetic and immunological analysis of inflammatory bowel disease in children
(Project Head
Klein, Christoph
)
Mechanisms and reversion of leukemia-induced tolerance in murine model systems
(Project Head
Klein, Christoph
)
Rare human diseases involving neutrophil granulocytes – new models to study trafficking and cell migration
(Project Head
Klein, Christoph
)
The effect of TRAIL on primary leukemia cells and leukemic stem cells
(Project Head
Jeremias, Ph.D., Irmela
)
The Role of the endosomal adapter molecule p14 in cytokine-receptor signal transduction and hematopoiesis
(Project Head
Klein, Christoph
)
Major Research Instrumentation
Completed projects
Durchflusszytometer
Hochleistungsflüssigchromatographie mit Kopplung an ein Triple Quadrupol Massenspektrometer (LC-MS/MS)
Konfokales Lasermikroskop
Sequenzierplattform
Zellanalyse- und Hochgeschwindigkeitssortiersystem
CRC/Transregios
Current projects
Deciphering genetic regulatory effects of nucleic acid immunity in human dendritic cell populations
(Project Head
Kim-Hellmuth, Sarah
)
Dissection and correction of human regulatory T cell dysfunctions by CRISPR engineering
(Project Heads
Kotlarz, Daniel
;
Schumann, Kathrin
)
Genetic regulation of protein expression during immune cell development in human neonates
(Project Heads
Kim-Hellmuth, Sarah
;
Nußbaum, Claudia Franziska
)
Studying inborn errors of immunity affecting neutrophil granulocytes
(Project Head
Klein, Christoph
)
Completed projects
Identification of novel biomarkers and underlying immune mechanisms for allergic and non-allergic asthma in childhood: prediction of outcome and translation to clinics
(Project Head
Schaub, Bianca
)
Metagenomic Determinants of Asthma Protection in Environmental Dust
(Project Heads
Ege, Ph.D., Markus
;
von Mutius, Erika
)
Service Platform Functional Genomics
(Project Heads
Buch, Thorsten
;
Legatzki, Antje
)
Research Training Groups
Completed projects
GRK 303: Infection and Immunity
(Spokesperson
Heesemann, Jürgen
)
GRK 1202: Oligonucleotides in Cell Biology and Therapy
(Spokesperson
Endres, Stefan
)
Graduate Schools
Completed projects
GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM)
(Spokesperson
Frey, Erwin
)
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