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Institution
Universitätsklinikum Erlangen AöR
Medizinische Klinik 3 - Rheumatologie und Immunologie
Internistisches Zentrum (INZ)
Address
Ulmenweg 18
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Research Grants
Current projects
B cells regulate bone remodeling in an AP-1 dependent manner
(Applicant
Grötsch, Bettina
)
Characterization of the pro-resolving eosinophil subset in human arthritis and its regulation by anti-rheumatic treatment
(Applicants
Bozec, Aline
;
Schett, Georg
)
Engrailed 1 mediates fibroblast activation and tissue fibrosis
(Applicant
Matei, Alexandru-Emil
)
Heterogeneity of neutrophil states in rheumatoid arthritis and systemic lupus
(Applicant
Grieshaber-Bouyer, Ricardo
)
Investigating the immunomodulatory abilities of Prevotella spp. promoting the development of rheumatoid arthritis
(Applicants
Strowig, Till
;
Zaiss, Mario M.
)
Molecular Assessment of the Acute Damage-Response in Stromal Resident Tissue Macrophages.
(Applicant
Uderhardt, Stefan
)
Mutual amplification of Hedgehog and Activator Protein 1 (AP1)-signaling in Systemic Sclerosis - potential therapeutic and prognostic implications
(Applicant
Bergmann, Christina
)
Networks of tissue responses in inflammatory diseases and cancer
(Applicant
Ramming, Andreas
)
Regulation of chromatin remodeling by Notch1 in fibrotic disorders
(Applicant
Dees, Clara
)
Role of popliteal lymph node stromal cells during the onset of rheumatoid arthritis
(Applicant
Zaiss, Mario M.
)
Targeting Dipeptidyl-peptidase-4 (DPP4) in systemic sclerosis and related fibrotic diseases
(Applicant
Ramming, Alina
)
The biphasic spatiotemporal role of serotonin in RA progression
(Applicants
Bader, Michael
;
Zaiss, Mario M.
)
The role of extracellular DNA traps in the development of sialadenitis and primary Sjögren´s Syndrome
(Applicant
Munoz, Ph.D., Luis
)
The role of X-linked inhibitor of apoptosis protein (XIAP) in Systemic Sclerosis and other fibrosing disorders
(Applicant
Bergmann, Christina
)
Completed projects
Analyse der Interaktion der HIV-1-spezifischen Immunantwort mit der Entwicklung von Resistenzen gegen die antiretrovirale Therapie
(Applicant
Harrer, Thomas
)
AP-1 transcription factors roles in the control of macrophage polarization
(Applicant
Bozec, Aline
)
Evaluation of ATF3 in systemic sclerosis and fibrotic diseases
(Applicant
Ramming, Andreas
)
Humane Autoantikörper gegen C-reaktives-Protein aus SLE-Patienten: Isolierung, Charakterisierung und Klärung ihrer Bedeutung für das Krankheitsgeschehen
(Applicant
Herrmann, Martin
)
Induktion von Hitzeschockprotein 90 durch Transforming Growth Factor ß als neuer pro-fibrotischer Signalweg in der systemischen Sklerose
(Applicant
Schett, Georg
)
Interleukin 9-induced tissue repair mechanisms in chronic inflammatory arthritis
(Applicant
Ramming, Andreas
)
Neutrophil extracellular traps form the nidus of human gall stones
(Applicant
Schauer, Ph.D., Christine
)
Nuclear Receptor 4a1 (Nr4a1) als negativer Rückkopplungsmechanismus bei fibrotischen Erkankungen
(Applicant
Akhmetshina-Distler, Ph.D., Alfiya
)
Pharmacological Blockade of Canonical Wnt Signaling for the Treatment of Systemic Sclerosis and Other Fibrotic Diseases
(Applicant
Beyer, Christian
)
Role of C-type lectin molecules in bone homeostasis
(Applicant
Bozec, Aline
)
The function of eosinophils in bone remodelling
(Applicant
Schett, Georg
)
The role of caspase activation in the regulation of osteoclast fusion and bone homeostasis
(Applicant
Scherbel, Carina
)
The role of PARP1 in the pathogenesis of fibrotic disorders
(Applicant
Dees, Clara
)
The role of Siglec-9/ Siglec-E in osteoclastogenesis
(Applicant
Steffen, Ulrike
)
The role of SOCS3 in the pathogenesis of fibrotic disorders
(Applicant
Dees, Clara
)
The role of the cartilage protein Ucma in degenerative and inflammatory arthritis
(Applicant
Stock, Michael
)
Untersuchung der Rolle der 12/15-Lipoxygenase in der Pathogenese der rheumatoiden Arthritis
(Applicant
Schett, Georg
)
Wnt5a activates fibroblasts and induces fibrosis via the planar cell polarity pathway
(Applicant
Distler, Jörg Hans Wilhelm
)
Research Units
Current projects
FOR 2886: PANDORA - Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis
(Spokesperson
Krönke, Gerhard
)
Machine learning-based in vivo assessment of the role of the synovial microenvironment in the pathogenesis of inflammatory arthritis
(Applicants
Breininger, Katharina
;
Uderhardt, Stefan
)
Completed projects
Bildgebende Charakterisierung und Quantifizierung der Vaskulogenese bei Arthritis
(Applicant
Schett, Georg
)
Impact of IgA and IgG ACPA on the immune system and disease onset
(Applicant
Steffen, Ulrike
)
Intestinal epithelial cell death as modulator of intestinal dysbiosis, systemic autoimmunity and the onset of Arthritis
(Applicants
Bozec, Aline
;
Günther, Claudia
)
Mechanisms of intestinal immune activation in RA – consequences for clinical onset
(Applicants
Rothhammer, Veit
;
Zaiss, Mario M.
)
Plasmazellen als therapeutischer Ansatzpunkt bei Antikörper-vermittelten Autoimmunerkrankungen
(Applicant
Voll, Reinhard
)
Sodium as factor controlling the threshold of autoimmune arthritis
(Applicant
Herrmann, Martin
)
The influence of mitochondrial lymphocyte metabolism on the onset of RA
(Applicants
Mielenz, Dirk
;
Schett, Georg
)
Translational Arthritis Database, crosslinking clinical and basic Research.
(Applicant
Pachowsky, Milena
)
Priority Programmes
Completed projects
Crosstalk between inflammation, bone destruction and new bone formation in patients with ankylosing spondylitis
(Applicant
Syrbe, Uta
)
Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss
(Applicants
Hofbauer, Lorenz C.
;
Rauner, Martina
)
Evaluation of the nuclear receptor Retinoid Acid Receptor related Receptor alpha (RORalpha) as a novel regulator of osteoclastogenesis in rheumatoid arthritis and osteoporosis
(Applicant
Distler, Jörg Hans Wilhelm
)
How Fra/AP-1 transcription factors control the bone niche
(Applicants
Bozec, Aline
;
Mielenz, Dirk
)
Innate Lymphoid Cells induce a fibrotic phenotype of fibroblasts in fibrotic diseases
(Applicant
Ramming, Andreas
)
Management and Dissemination of Priority Program SPP 1468 "Osteoimmunology - IMMUNOBONE - A Programm to Unravel Mutual lnteractions between the Immune System and Bone"
(Applicant
Schett, Georg
)
Relevance of osteal macrophages in bone remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
SPP 1468: Osteoimmunology - IMMUNOBONE - A Programme to Unravel the Mutual Interactions between the Immune System and Bone
(Spokesperson
Schett, Georg
)
The impact of ACPA on bone loss in patients with rheumatoid arthritis
(Applicant
Schett, Georg
)
The role of adipocytes in the bone tumor micro-environment
(Applicants
Bozec, Aline
;
Bäuerle, Tobias
)
The role of CXCR2-ligands for neutrophil mobilization from the bone marrow to peripheral sites
(Applicants
Gunzer, Matthias
;
Waisman, Ari
)
The role of innate lymphoid cells (ILCs) in the modulation of Arthritis by intestinal helminthes
(Applicant
Zaiss, Mario M.
)
The role of MAPK-activated protein kinase-2 and -3 in bone homeostasis and inflammatory bone destruction
(Applicant
Schett, Georg
)
The role of the oxidative burst in bone remodeling during chronic inflammation
(Applicants
Herrmann, Martin
;
Hoffmann, Markus
)
The Role of the Wnt antagonist Wif-1 in bone remodelling during arthritis
(Applicant
Schett, Georg
)
Independent Junior Research Groups
Completed projects
Organ cross-talk controlled by transcription factors, nutrients and cytokines: bone homeostasis and cancer
(Applicant
Bozec, Aline
)
Heisenberg Grants
Current projects
Assessing tissue-protective functions of macrophages through integrative and functional tissue-level biology.
(Applicant
Uderhardt, Stefan
)
Collaborative Research Centres
Current projects
Hand Motion Patterns Derived from Empathokinaesthetic Sensor Data as a Diagnostic Parameter for Disease Activity in Patients with Rheumatic Diseases
(Project Heads
Kleyer, Arnd
;
Liphardt, Anna-Maria
;
Schett, Georg
)
Completed projects
Amplification of NET formation and neutrophil aggregation for the resolution of inflammation
(Project Heads
Herrmann, Martin
;
Hoffmann, Markus
)
Analyse der HIV-spezifischen zytotoxischen T-Zellantwort: Analyse viraler Fluchtmechanismen und Entwicklung von medikamentösen und immunologischen Therapiestrategien
(Project Head
Harrer, Thomas
)
Bedeutung von anti-dsDNA-Antikörpern für die Pathogenese der Lupusnephritis
(Project Heads
Kalden, Joachim R.
;
Winkler, Thomas
)
Central tasks of the CRC1181
(Project Head
Schett, Georg
)
Characterization of the pro-resolving eosinophil subset in human arthritis and its regulation by anti-rheumatic treatment
(Project Heads
Bozec, Aline
;
Schett, Georg
)
Determining the molecular pathways of the effects of regulatory T cells on monocytes/osteoclasts
(Project Head
Schett, Georg
)
Genese des löslichen Transferrinrezeptors und seine Bedeutung für die Regulation der Aktivierung entzündlicher Effektorzellen
(Project Head
Manger, Bernhard
)
Immune modulation by ligands of dead and dying cells
(Project Head
Herrmann, Martin
)
Integrated Research Training Group
(Project Heads
Koop, Kristina
;
Zaiss, Mario M.
)
Integrated Research Training Group (IRTG)
(Project Heads
Herrmann, Martin
;
Schleicher, Ulrike
)
Interaktionen zwischen Synovialen Zellen und Gelenkknorpel - Untersuchung zellulärer und molekularer Grundlagen der Knorpelzerstörung bei der Rheumatoiden Arthritis (RA)
(Project Head
Geiler, Thomas
)
Mechanismen der Transduktion stimulatorischer und inhibitorischer Signale über die akzessorischen Moleküle CD28 und CTLA-4 auf T-Lymphozythen
(Project Heads
Manger, Bernhard
;
Nagel, Thomas
)
Microbial-derived histamine induces resolution of synovial inflammation via the CNS
(Project Heads
Rothhammer, Veit
;
Zaiss, Mario M.
)
Modification of cytokines by myeloperoxidase activity and (un)known mediators in resolution of psoriatic disease
(Project Heads
Frey, Silke
;
Hüffmeier, Ulrike
;
Steffen, Ulrike
)
Molekularbiologische Charakterisierung von Nukleinsaeuren aus dem Plasma von Patienten mit SLE
(Project Head
Krapf, F. E.
)
Remutation von klonalen anti-dsDNA Antikörpern
(Project Head
Kalden, Joachim R.
)
SFB 1181: Checkpoints for Resolution of Inflammation
(Spokesperson
Schett, Georg
)
The role of p38MAPKá in rapid progressive crescentic glomerulonephritis
(Project Heads
Schett, Georg
;
Zwerina, Jochen
)
The role of Siglecs and sialic acids in the resolution of inflammation
(Project Heads
Nitschke, Lars
;
Steffen, Ulrike
)
The spatial transcriptomic landscape of resolution of inflammation in arthritis
(Project Heads
Ramming, Andreas
;
Rauber, Simon
)
Research Fellowships
Completed projects
Investigations on antigen-dependent and -independent functions of distinct myeloid subsets of phagocytes in host defence and maintenance of self-tolerance during infection and inflammation
(Applicant
Uderhardt, Stefan
)
Relationship of bone quality, muscle performance and body composition in osteopenic women, high performance athletes and young adults with eating disorders & changes in bone quality measured with 3D HR-pQCTafter vibration training in osteopenic women
(Applicant
Liphardt, Anna-Maria
)
Clinical Research Units
Current projects
KFO 5024: Immune checkpoints of gut to brain communication in inflammatory and neurodegenerative diseases (GB.Com)
(Spokesperson
Winner, Beate
)
Studying in situ tissue schematics using advanced volumetric imaging and machine learning for image analysis.
(Applicants
Breininger, Katharina
;
Uderhardt, Stefan
)
Completed projects
Neutrophil extracellular traps orchestrate the immune response in Inflammatory Bowel Diseases
(Applicants
Herrmann, Martin
;
Leppkes, Moritz
)
Major Research Instrumentation
Completed projects
Lichtblattfluoreszenzmikroskop
Clinical Trials
Current projects
Influence of the short-chain fatty acid propionate as a metabolite of the human intestinal microbiome in the context of arthritic diseases.
(Applicant
Zaiss, Mario M.
)
CRC/Transregios
Current projects
Arginine supplementation as new therapeutic option against inflammatory bone loss
(Project Heads
Bozec, Aline
;
Schleicher, Ulrike
)
Central Management Project
(Project Head
Bozec, Aline
)
Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
;
Schett, Georg
;
Tsourdi, Elena
)
Cross talk between skin and joints impairs bone homeostasis in psoriatic arthritis
(Project Heads
Günther, Claudia
;
Ramming, Andreas
)
Emergency barriers in Inflammatory Bowel Diseases- Neutrophil-epithelial interplay shapes epithelial restitution in the ulcer microenvironment
(Project Heads
Herrmann, Martin
;
Koop, Kristina
;
Leppkes, Moritz
)
Inflammation-induced intestinal epithelial regulated necrosis as a novel modulator of bone resorption
(Project Heads
Bozec, Aline
;
Günther, Claudia
)
Kidney imaging and ultrastructure
(Project Heads
Uderhardt, Stefan
;
Warth, Richard
;
Witzgall, Ralph
)
Regulatory mechanisms linking chronic gut inflammation and bone loss
(Project Heads
Wielockx, Ph.D., Ben
;
Zaiss, Mario M.
)
Resolving glomerular to tubular crosstalk through miR-containing exosomes
(Project Heads
Müller-Deile, Janina
;
Uderhardt, Stefan
)
Role for the c-type lectin receptor Dectin-1 (Clec7a) in inflammatory bone disease
(Project Heads
Grötsch, Bettina
;
Weber, Manuel
)
Role of type I interferon in inflammatory bone disease
(Project Heads
Lee-Kirsch, Min Ae
;
Schett, Georg
)
The impact of neutrophils and NET formation on osteoclastogenesis and bone homeostasis during inflammation
(Project Head
Steffen, Ulrike
)
The role of the iron regulator transferrin receptor 2 in infection and bone
(Project Heads
Baschant, Ulrike
;
Scholtysek, Carina
)
Tissue-level definition of the inflammatory osteoclastogenic niche
(Project Heads
Gölz, Lina
;
Uderhardt, Stefan
)
TRR 369: DIONE Degeneration of bone induced by inflammation
(Spokesperson
Bozec, Aline
)
Research Training Groups
Current projects
GRK 2504: Novel antiviral approaches: from small molecules to immune intervention
(Spokesperson
Überla, Klaus
)
GRK 2599: FAIR - Fine-Tuners of the Adaptive Immune Response
(Spokesperson
Zaiss, Mario M.
)
GRK 2740: Immunomicrotope: Microenvironmental, Metabolic and Microbial Signals Regulating Immune Cell-Pathogen Interactions
(Spokesperson
Bogdan, Christian
)
Completed projects
GRK 592: Lymphocytes: Differentiation, Activation and Deviation
(Spokesperson
Jäck, Hans-Martin
)
GRK 1071: Viruses of the Immune System
(Spokesperson
Fleckenstein, Bernhard
)
GRK 1660: Key Signals of Adaptive Immune Response
(Spokesperson
Jäck, Hans-Martin
)
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