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Medizinische Hochschule Hannover
Zentrum Innere Medizin
Klinik für Gastroenterologie, Hepatologie und Endokrinologie

Address Carl-Neuberg-Straße 1
30625 Hannover
Deutschland

GERiT This institution in GERiT

30625 Hannover

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Priority Programmes
- Completed projects
  - Investigations on epigenetic modulation during pre-implantation embryonic gene expression and its significance for the incidence of the large offspring syndrome
    (Applicant Niemann, Heiner )
  - Zell- und molekularbiologische Analyse von De- und Redifferenzierungsvorgängen in porcinen und bovinen Kardiomyozyten in einem homologen und heterologen Kerntransfermodell
    (Applicant Niemann, Heiner )
Clinical Research Units
- Completed projects
Reinhart Koselleck Projects
- Completed projects
  - In vivo tissue engineering of patient specific chimeric liver tissue for whole organ liver transplantation
    (Applicants Niemann, Heiner ; Ott, Michael )
Research Units
- Current projects
  - Deciphering the transport metabolomes of SLC26A3, SLC26A6 and SLC26A9 in the human gastrointestinal tract
    (Applicant Seidler, Ursula )
  - FOR 5046: Integrated analysis of epithelial SLC26 anion transporters - from molecular structure to pathophysiology
    (Spokesperson Oliver, Dominik )
- Completed projects
  - Epigenetische Analyse der Eizell- und Embryonalentwicklung am Modellorganismus Rind
    (Applicants Haaf, Thomas ; Niemann, Heiner ; Wrenzycki, Christine )
  - Improved multi-transgenic pig lines for xenotransplantation
    (Applicant Niemann, Heiner )
  - In vitro Germ Cell Differentiation of Cord-Blood-derived Unrestricted Somatic Stem Cells (USSC)
    (Applicant Schöler, Hans Robert )
  - Transcriptomics des präimplantativen Rinderembryos
    (Applicants Adjaye, James ; Niemann, Heiner )
Heisenberg Grants
- Current projects
  - Developing RNA therapeutics for liver via in vivo cellular reprogramming and remodeling of hepatic cells
    (Applicant Sharma, Ph.D., Amar Deep )
Collaborative Research Centres
- Completed projects
CRC/Transregios
- Completed projects
  - Core facility for genetically engineered pig lines
    (Project Heads Kaup, Franz-Josef ; Keßler, Barbara ; Kues, Wilfried A. ; Lucas-Hahn, Andrea ; Niemann, Heiner ; Petersen, Björn ; Schnieke, Angelika ; Wolf, Eckhard )
  - Evaluation of Apoptosis Biomarkers that Determine the Chemosensitivity of Hepatocellular Carcinoma and Early Identification of Non-Responders to Anticancer Therapy
    (Project Heads Bantel, Heike ; Lehner, Frank )
  - Identification and functional characterization of cancer cell-derived, stroma-modulating factors in cholangiocarcinoma
    (Project Heads Saborowski, Anna Lena ; Saborowski, Michael )
  - Identification of Melecular Targets for Immune-Based Therapies in Hepatocellular Carcinoma
    (Project Heads Greten, Tim F. ; Korangy, Firouzeh ; Wirth, Thomas )
  - Identification of molecular mechanisms conferring resistance to oncolytic viruses in HCC and implications for successful HCC virotherapy
    (Project Heads Eggert, Tobias ; Kühnel, Florian ; Lauer, Ulrich M. )
  - Microsphere-based immuno-therapy of HCC
    (Project Head Wirth, Thomas )
  - Modifying the porcine genome for xeno-organ transplantation
    (Project Heads Fischer, Konrad ; Kues, Wilfried A. ; Lucas-Hahn, Andrea ; Niemann, Heiner ; Petersen, Björn ; Schnieke, Angelika )
  - Optimization and evaluation of c-myc – directed liver cancer therapy
    (Project Head Vogel, Arndt )
  - Preclinical assessment of decellularised (antigen-reduced), gene-modified porcine heart valves
    (Project Heads Büttner, Falk ; Cebotari, Serghei ; Haverich, Axel ; Hilfiker, Andres ; Martin, Ulrich ; Niemann, Heiner )
  - Regulatory T cells (Tregs) in xenotransplantation
    (Project Heads Jaeckel, Elmar ; Noyan, Fatih ; Pohla, Heike )
  - Role off c-myc in Chronic Liver Injury and Hepatocarcinogenesis
    (Project Head Vogel, Arndt )
  - Targeting the mutanome of liver cancer by viral oncoly-sis and tumor-directed immunotherapies
    (Project Head Kühnel, Florian )
  - Viroimmunotherapy in HCC: Recruitment and Expansion of Dendritic Cells by Tumor-Specific Replicating Viruses
    (Project Heads Kubicka, Stefan ; Kühnel, Florian )
Major Research Instrumentation
- Completed projects
  - Flow cytometer
WBP Fellowship
- Current projects
  - Characterizing the tumor microenvironment of MASH-related HCC to unravel determinants of response and/or resistance to atezolizumab + bevacizumab
    (Applicant Almeida Valadas De Castro, Tiago )
Clinical Trials
- Current projects
  - Randomized, prospective, multicenter, open-label, controlled, parallel-group trial investigating the efficacy of add-on plasma-exchange as an adjunctive strategy against septic shock - 2 (EXCHANGE-2)
    (Applicant David, Sascha )
- Completed projects
  - Biliary Interventions in critically ill patients with Sclerosing Cholangitis
    (Applicant Wedemeyer, Heiner )
International Research Training Groups
- Completed projects
  - GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections
    (Spokesperson Suerbaum, Sebastian )
  - GRK 1549: Molecular and Cellular Glyco-Sciences (MCGS). Understanding Structure/Function Relationships of Carbohydrate/Protein Interactions
    (Spokesperson Moerschbacher, Bruno )
Clusters of Excellence
- Completed projects
  - EXC 62: From Regenerative Biology to Reconstructive Therapy (REBIRTH)
    (Spokespersons Haverich, Axel ; Thum, Ph.D., Thomas )
Graduate Schools
- Completed projects
  - GSC 108: Hannover Biomedical Research School (HBRS)
    (Spokesperson Schmidt, Reinhold Ernst )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2155: RESIST - Resolving Infection Susceptibility
    (Spokespersons Förster, Reinhold ; Hansen, Gesine ; Schulz, Thomas )

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